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KMID : 0363320000210030477
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Journal of Korean Oriental Internal Medicine
2000 Volume.21 No. 3 p.477 ~ p.486
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Effects of Gami-oryungsan on Antioxidation in Rat’s Liver
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Kim Hyeong-Hwan
Kim Mi-Rang
Park Chul-Soo
Kim Jong-Dae
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Abstract
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Objective : This is the experimental paper to investigate the effects of Gami-oryungsan(GO) on decreasing the activities of free radicals.
Methods : We used three different group; In the normal group, we injected Gami-oryungsan extract intraperitoneally daily for 15days(90mg/kg), bromobenzene(310mg/kg) for 2days and injected normal saline in the control group.
Results : We have observed the effects of Gami-oryungsan about the damage of rat’s liver induced by bromobenzene. We can find the level of lipid peroxidation and type conversion ratio of xanthine oxidase decreased compared to the case of bromobenzene-treated group. The enzyme of activities of superoxide dismutase, catalase and glutathione peroxidase highly increased in Gami-oryungsan pre-acupunctured group compared to the group treated with only bromobenzene. The level of glutathione in Gami-oryungsan pre-acupunctured group was increased as highly as normal group. Also it was not seen special effects concerning aldehyde oxidase.
Conclusions : Gami-oryungsan extract recovers the damage of liver due to bromobenzene intoxication by decreasing the lipid peroxidation
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